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根據(jù)ROC曲線確定的界值，galectin-3、CEA及CA199診斷胰腺癌的陽性率分別為33.3%、50.0%及63.3%。3項(xiàng)指標(biāo)中g(shù)alectin-3雖然敏感性較低，但其有較高的特異性，CEA及CA199對胰腺癌的診斷敏感性相差不多，但CA199診斷特異性要略優(yōu)于CEA。3項(xiàng)指標(biāo)都存在診斷敏感性或診斷特異性不太高的缺陷，因此單獨(dú)檢測galectin-3、CEA及CA199診斷胰腺癌均有局限性。聯(lián)合檢測能夠在一定程度上彌補(bǔ)單一指標(biāo)檢測的不足，三者對胰腺癌的診斷存在互補(bǔ)價(jià)值，二項(xiàng)聯(lián)合檢測組合以galectin-3加CA199最優(yōu)，既可提高診斷敏感性，又不會明顯降低特異性。3項(xiàng)聯(lián)合檢測雖會使診斷特異性有所下降，可明顯提高診斷敏感性，對胰腺癌的篩查具有重要臨床價(jià)值。Galectin-3作為對傳統(tǒng)胰腺癌標(biāo)志物的補(bǔ)充對胰腺癌早期診斷及鑒別診斷具有十分重要的意義，galectin-3有可能成為胰腺癌的重要血清標(biāo)志物之一。
因本實(shí)驗(yàn)中g(shù)alectin-3的檢測為雙抗體夾心生物素-親和素ELISA法，其檢測敏感性不太高，不能檢測出微量的galectin-3，可能是導(dǎo)致胰腺癌陽性率不太高的原因之一。今后我們將研究開發(fā)更敏感的檢測方法，進(jìn)一步擴(kuò)大病例數(shù)，深入研究galectin-3作為胰腺癌標(biāo)志物的臨床意義。
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