醫(yī)學論文范文:總膽紅素與老年高血壓患者低密度脂蛋白及白蛋白關系的探討

醫(yī)學論文范文:總膽紅素與老年高血壓患者低密度脂蛋白及白蛋白關系的探討

【摘要】 目的 探討血清總膽紅素與老年高血壓患者低密度脂蛋白、白蛋白的關系。方法 243例老年人,單純高血壓組60例,高血壓肥胖組62例,對照組121例。測定3組的血清總膽紅素、白蛋白、甘油三酯、高密度脂蛋白膽固醇、總膽固醇、低密度脂蛋白膽固醇,并對數(shù)據進行分析。結果 老年男性總膽紅素高于老年女性,總膽紅素與老年男性白蛋白及老年女性低密度脂蛋白膽固醇正相關。單純高血壓組老年男女總膽紅素低于對照組,男性單純高血壓組與對照組比較差異有顯著性意義;女性則差異無顯著性意義。單純高血壓組老年人低密度脂蛋白膽固醇低于、高血壓肥胖組老年人高于對照組,但差異無顯著性意義。老年男性高血壓組總膽紅素與低密度脂蛋白膽固醇不相關,老年女性單純高血壓組總膽紅素與低密度脂蛋白膽固醇正相關,與白蛋白不相關。結論 老年女性高血壓患者總膽紅素隨低密度脂蛋白膽固醇水平的增高而增高,血清白蛋白與老年男性總膽紅素有關聯(lián)。性別及增齡對高血壓患者總膽紅素水平可能有一定影響。

【關鍵詞】 高血壓; 總膽紅素; 低密度脂蛋白膽固醇; 白蛋白; 老年人

Relationship between serum total bilirubin and low�瞕ensity lipoprotein,albumin in elderly patients with hypertension

SUN Yan,LIAO Shu�瞤ing,LIU Yang

(Department of Medical Examination,Second Affiliated Hospital,Jinan Medical University,Shenzhen Guangdong 518020,China)

【Abstract】 Objective To study the relationship between serum total bilirubin(T�睟ili) and low�瞕ensity lipoprotein(LDL�睠),serum albumin in elderly patients with essential hypertension.Methods We selected 60 patients with essential hypertension only(hypertensionⅠgroup),62 overweight or obese senile people with essential hypertension(hypertensionⅡgroup)and 121 healthy control subjects(control group).The T�睟ili,Alb,LDL�睠,TG,HDL�睠 and TC of all cases were determined and statistical analyses were performed.Results The T�睟ili was higher in elderly men than that in elderly women(P<0.05).Compared with control group,the male hypertensionⅠgroup showed lower T�睟ili level(P<0.05).There was positive correlation between T�睟ili and LDL�睠 in elderly women(P<0.05) as well as serum albumin in elderly men(P<0.05).The T�睟ili also had positive correlation with LDL�睠 in female hypertensionⅠgroup(P<0.05).There was no correlation between T�睟ili and LDL�睠 in male hypertension subjects.Conclusion The level of T�睟ili appears to increase along with rising of LDL�睠 in elderly women with hypertension.There is a correlation between T�睟ili and concentration of serum albumin in elderly male.Gender and aging may affect the T�睟ili level in hypertension subjects.

【Key words】 hypertension;bilirubin;low�瞕ensity lipoprotein;albumin;aged

高血壓與動脈粥樣硬化相關,而動脈粥樣硬化的形成與低密度脂蛋白被氧化進而損傷血管內皮細胞有關[1]。文獻報道膽紅素的不同形式均具有抗氧化作用,能阻止低密度脂蛋白被氧化,防止動脈粥樣硬化的發(fā)生[2],當膽紅素等抗氧化劑被消耗呈低水平時,低密度脂蛋白的氧化修飾增加[3]。白蛋白也是內源性抗氧化劑,可防止氧自由基對膜脂質等的過氧化作用[4],高血壓患者總膽紅素與低密度脂蛋白膽固醇負相關[5]。老年階段常見高血壓,我們聚焦于老年高血壓患者,觀察其血清總膽紅素、低密度脂蛋白膽固醇及白蛋白水平及其相互關系醫(yī)學 全在.線提供gydjdsj.org.cn。

1 資料與方法

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