 |
 |
醫(yī)學論文范文:清熱降濁方對2型糖尿病合并代謝綜合征患者胰島β細胞功能的影響
【摘要】 目的 探討清熱降濁方對2型糖尿病合并代謝綜合征患者胰島β細胞功能的影響。方法 采用隨機對照的臨床試驗,觀察清熱降濁方(治療組)與二甲雙胍(對照組)對208例2型糖尿病合并代謝綜合征患者糖化血紅蛋白(HbA1c)、空腹血糖(FBG)、餐后2 h血糖(P2BG)、總膽固醇(TC)、三酰甘油(TG)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)、體重、體重指數(shù)(BMI)、腰圍及胰島素抵抗指數(shù)(HOMA2-IR)、胰島素敏感指數(shù)(HOMA2-S)、胰島β細胞功能指數(shù)(HOMA2-B)的影響。結果 2組患者治療后HbA1c、FBG和P2BG水平均較治療前明顯下降(P<0.001),組間差異無統(tǒng)計學意義;TC、TG、LDL-C水平較治療前均有所下降,但對HDL-C的作用不明顯。治療組體重與BMI下降明顯,優(yōu)于對照組(P<0.05)。2組HOMA2-IR、HOMA2-S、HOMA2-B的改善不明顯。結論 清熱降濁方對2型糖尿病合并代謝綜合征患者各項指標的影響與二甲雙胍相當,但對胰島β細胞功能的改善不明顯。
【關鍵詞】 清熱降濁方;二甲雙胍;2型糖尿病;代謝綜合征;胰島β細胞功能
Effect of Qingre-Jiangzhuo Prescription on Islet β Cell Function of Type 2 Diabetes Mellitus Combined Metabolic Syndrome Patients ZHU Yan, LIAN Feng-mei, TONG Xiao-lin (Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China醫(yī)學.全在線gydjdsj.org.cn)
Abstract：Objective To evaluate the effect of Qingre-Jiangzhuo prescription on islet β cell function of type 2 diabetes mellitus (T2DM) combined metabolic syndrome patients. Methods Two hundred and eight T2DM patients were divided into 2 groups in a randomized, controlled clinical trail. One group was treated by metformin tablet and the other by Qingre-Jiangzhuo prescription, both for 12 weeks. HbAlc, FBG, P2BG, TC, TG, LDL-C, BW, BMI, WC and HOMA2-IR, HOMA2-S, HOMA2-B level before and after treatment were recorded. Results After treatment, FBG, P2BG and HbAlc of the treated group were significantly lower than that before treatment (P<0.001), the difference between the two groups was not significant. TC, TG and LDL-C of both groups were significantly lower than that before treatment, but not in HDL-C. Weight and BMI were significantly decreased in the treated group compared with the control group (P<0.05). But the difference in HOMA2-IR, HOMA2-S, HOMA2-B were not significant. Conclusion Qingre-Jiangzhuo prescription was same as metformin tablet in T2DM combined metabolic syndrome patients, while not in β cell function.
Key words：Qingre-Jiangzhuo prescription;metformin;T2DM;MS;islet β cell function
前期研究顯示,清熱降濁方與二甲雙胍有相似的降糖、調(diào)脂、減肥等作用,且安全性良好[1-2]。為進一步探討清熱降濁方對2型糖尿病合并代謝綜合征患者胰島β細胞功能的影響,筆者擬通過隨機對照的臨床試驗,對患者的胰島素抵抗指數(shù)(HOMA2-IR)、胰島素敏感指數(shù)(HOMA2-S)、胰島β細胞功能指數(shù)(HOMA2-B)進行觀察。
1 資料與方法
