醫(yī)學(xué)論文范文:鷹嘴豆芽與原釩酸鈉對糖尿病大鼠的降糖作用

醫(yī)學(xué)論文范文:鷹嘴豆芽與原釩酸鈉對糖尿病大鼠的降糖作用

【摘要】 目的 研究鷹嘴豆及豆芽與低劑量原釩酸鈉聯(lián)合使用的減毒、降糖作用。方法 以鏈脲佐菌素(streptozotocin, STZ)誘導(dǎo)形成糖尿病大鼠模型，鷹嘴豆及豆芽和原釩酸鈉分別單獨和聯(lián)合服用4周，觀察大鼠血糖和血脂等的變化。結(jié)果 與正常對照組比較，糖尿病組血糖升高了4倍，血漿胰島素(insulin, INS)降低了57.63%，血漿脂質(zhì)水平明顯異常，肝腎功能明顯受損。而分別單獨和聯(lián)合口服鷹嘴豆及豆芽和原釩酸鈉4周后，糖尿病大鼠的上述指標均得到改善，其中以鷹嘴豆芽聯(lián)合低劑量原釩酸鈉(0.2?mg/mL)治療組(D+Ps+V)效果最明顯：血糖降低了72.24%(P<0.05);血漿胰島素水平接近正常;血漿脂質(zhì)水平、葡萄糖耐量、肝腎功能均得到改善。結(jié)論 鷹嘴豆及豆芽和原釩酸鈉均能改善糖尿病大鼠高血糖的發(fā)展狀況和血漿脂質(zhì)水平的變化狀況;鷹嘴豆芽與原釩酸鈉聯(lián)合應(yīng)用療效最佳，既降低了釩毒性又增強了兩者的抗糖尿病作用。

【關(guān)鍵詞】 原釩酸鈉;鷹嘴豆;糖尿病;大鼠，Wistar

MAO Xue�瞦in1,3, ZHANG Ling2, WANG Meng�瞲in3, LIU Min�瞴ing4, SUN Zhao�瞗eng2,

ZHAO Xiao�瞞in2, XIA Zuo�瞝i1，2, YANG Xiao�瞕a5

(1. Institution of Physiology, School of Medicine, Shandong University, Jinan 250012, China;

2. Institution of Life Science, Taishan Medical University, Taian 271000, Shandong, China;

3. Department of Psychology, Qilu Hospital of Shandong University, Jinan 250012, China;

4. Capital Office, West Campus, Shandong University, Jinan 250012, China; 5. National Laboratory of Natural and

Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China)醫(yī).學(xué)全.在.線網(wǎng)站gydjdsj.org.cn

To investigate the improved hypoglycemic effects of low�瞕osage sodium�瞣rthovanadate (SOV), chickpea (Cicer arietinum) and chickpea embryos on experimental diabetes. Methods Streptozotocin (STZ)�瞚nduced diabetic rats were used in this experiment. After oral administration of chickpea, chickpea embryos and SOV separately and in combination for 4 weeks, the blood glucose and lipid profile were determined. Results A single intravenous injection of STZ (45?mg/kg) caused a 4�瞗old increase in the blood glucose level and 57.63% decrease in the serum insulin level. Levels of triglycerides and total cholesterol in serum markedly increased during diabetes. The hepatic and renal functions were heavily impaired during diabetes. Administration of SOV, chickpea and chickpea embryos separately or in combination inhibited development of hyperglycemia and alterations in the lipid profile in plasma. A low dose of SOV (0.2?mg/ml) combined with chickpea embryo a was most effective by decreasing the blood glucose by 72.24%, decreasing the improving glucose tolerance, and ameliorating the impaired hepatic and renal functions in diabetic rats. Conclusion SOV and chickpea are potential biological anti�瞕iabetic agents. Chickpea or chickpea embryos combined with low�瞕osage SOV (0.2?mg/ml) may enhance bio�瞐vailability by reducing SOV toxicity and improve the altered carbohydrate and lipid metabolism during experimental diabetes.

[1] [2] [3] 下一頁