醫(yī)學(xué)論文范文:2型糖尿病合并非酒精性脂肪肝相關(guān)因素分析

醫(yī)學(xué)論文范文:2型糖尿病合并非酒精性脂肪肝相關(guān)因素分析

【摘要】 目的：探討2型糖尿病(type 2 diabetes mellitus,T2DM)合并非酒精性脂肪肝( non alcoholic fatty liver disease,NAFLD)的臨床相關(guān)因素。方法：對(duì)新疆醫(yī)科大學(xué)第五附屬醫(yī)院2008年1～6月的269例糖尿病住院患者進(jìn)行回顧性分析,根據(jù)腹部B超結(jié)果分為合并NAFLD組148例,不合并NAFLD組121例。結(jié)果：與不合并NAFLD組比較，合并NAFLD的T2DM患者的體重指數(shù)(BMI)、腰圍、血甘油三酯(TG)、低密度脂蛋白(LDL�睠)、舒張壓(DSP)顯著增高(P均<0.05)：同時(shí)高密度脂蛋白(HDL�睠)顯著降低(P<0.05);Logistic回歸分析顯示：BMI、DBP、TG、LDL�睠、HDL�睠對(duì)T2DM合并的NAFLD的發(fā)生有顯著影響(P均<0.05)。結(jié)論：2型糖尿病患者合并非酒精性脂肪肝，與肥胖(主要是腹型肥胖)、血脂紊亂、血壓增高相關(guān);而與糖尿病病程、血糖控制程度、糖尿病并發(fā)癥不相關(guān)，導(dǎo)致糖尿病合并非酒精性脂肪肝的最主要原因?yàn)?a class="channel_keylink" href="/pharm/2009/20090113073450_104433.shtml" target="_blank">胰島素抵抗及其所包含的脂代謝紊亂。

【關(guān)鍵詞】 2型糖尿病 非酒精性脂肪肝 相關(guān)因素

A clinical study of relative factors in type 2 diabetes complicated with non alcoholic fatty liver disease

LI Xu�瞗ang, Yiliduosi·Aihetamofu, GAO Jing醫(yī).學(xué)全.在.線網(wǎng)站gydjdsj.org.cn

(Department of Endocrinology, First Affiliated Hospital, Xinjiang Medical University,Urumqi 830011, China)

Abstract: Objective: To analyze the clinical relative factors in type 2 diabetes mellitus (T2DM) complicated with non alcoholic fatty liver disease. Methods: A total of 269 type 2 diabetes were selected in the Department of Endorcrinoloy, Five Affiliated Hospital, Xijiang Medical University, from January 2008 to June 2008.According to the color B�瞮ltrasonography detection of liver and gall, these subjects were divided into fatty liver group (n=148) and without fatty liver group (n=121). Results: Compared with the T2DM patients without NAFLD, the figures of BMI, waistline (WL), serum TG levels, serum LDL�睠 levels and diastolic blood pressure increased significantly in the T2DM patients with NAFLD (P<0.05), while the serum HDL�睠 levels decreased significantly (P<0.05);Logistic regression analysis suggested that BMI, WL, DSP, TG, LDL�睠, HDL�睠 were significantly effected of the forming of T2DM with NAFLD (P<0.05). Conclusion: Obesity(ventro�瞭ype obesity), dyslipidosis, blood pressure increased were remarkably correlated with T2DM with NAFLD; and course of diabetes disease, the degree of blood glucose control were not correlated with T2DM with NAFLD， insulin resistance and it cause of dyslipidosis are main reason of T2DM with NAFLD.

Key words: type 2 diabetes mellitus; non alcoholic fatty liver disease; clinical relative factors

隨著人們生活水平的提高、生活方式的改變，2型糖尿病(T2�睤M)合并非酒精性脂肪肝(non alcoholic fatty liver disease,NAFLD)在臨床上呈升高趨勢(shì)。非酒精性脂肪肝進(jìn)一步可以發(fā)展為肝炎、肝纖維化以及肝硬化[1]。因此，我們分析糖尿病合并NAFLD與不合并NAFLD患者的一些臨床指標(biāo)，明確其相關(guān)因素，為防治糖尿病合并非酒精性脂肪肝提供依據(jù)。

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