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綜上所述，通過PEI示蹤染色對(duì)AN大鼠AS表達(dá)和分布的研究，證實(shí)了AN大鼠GBM上AS與蛋白尿之間的相關(guān)性。AS是GBM電荷屏障功能正常的重要標(biāo)志之一，祛風(fēng)通絡(luò)方可能通過改善AN大鼠GBM上HSPG的表達(dá)而改善AS的表達(dá)和分布，修復(fù)GBM電荷屏障，從而起到防治腎性蛋白尿的作用。但其影響基底膜相關(guān)蛋白之間的信號(hào)轉(zhuǎn)導(dǎo)以及內(nèi)在的調(diào)節(jié)機(jī)制還有待深入研究。
【參考文獻(xiàn)】
[1]孫萬森，吳喜利，喬成林，等. 通絡(luò)膠囊治療糖尿病腎病慢性腎衰竭的臨床研究 [J]. 中國(guó)中西醫(yī)結(jié)合雜志, 2004, 24(8):704-706.
[2]GOLDBERG S, HARVEY SJ, CUNNINGHAM J, et al. Glomerular filtration is normal in the absence of both agrin and perlecan-heparan sulfate from the glomerular basement membrane [J]. Nephrol Dial Transplant, 2009, 14. [ahead of print]
[3]HERTZAN-LEVY S, FISH R, SKUTELSKY E, et al. Glomerular basement membrane anionic sites in adriamycin nephropathy: effect of saline loading and nitric oxide modulation [J]. Nephron, 2000, 84(4):354-361.
[4]FUJIGAKI Y, BATSFORD S, YAMASHITA F, et al. Sequence of events in the glomerular capillary wall at the onset of proteinuria in passive Heymann nephritis [J]. Virchows Arch, 2001, 438(2):136-145.
[5]邢玲玲，傅淑霞. 腎小球陰電荷的檢測(cè)方法及臨床意義 [J]. 河北醫(yī)科大學(xué)學(xué)報(bào), 2004, 25(5):319-321.
[6]ISOGAI S, MOGAMI K, OUCHI H, et al. An impairment of barrier size and charge selectivity of glomerular basement membrane in streptozotocin-induced diabetes and prevention by pharmacological therapy [J]. Med Electron Microsc, 2000, 33(3):123-129.醫(yī).學(xué)全.在.線網(wǎng)站www.gydjdsj.org.cn
[7]YAMASHITA H, NAGAI Y, TAKAMURA T, et al. Thiazolidinedione derivatives ameliorate albuminuria in streptozotocin-induced diabetic spontaneous hypertensive rat [J]. Metabolism, 2002, 51(4):403-408.
[8]王新良，王新穎，牟兆新，等. 腎缺血再灌注對(duì)大鼠腎小球超微結(jié)構(gòu)及負(fù)電荷位點(diǎn)的影響[J]. 河北醫(yī)科大學(xué)學(xué)報(bào), 2005, 26(5):321-323.
[9]李維軍，王健，章文平. 通腎湯對(duì)腎小球基底膜陰離子位點(diǎn)的影響 [J]. 江西中醫(yī)學(xué)院學(xué)報(bào), 2004, 16(5):46.
[10]魯艷芳，袁軍，林麗，等. 中西醫(yī)結(jié)合對(duì)腎病模型腎小球基底膜陰離子位點(diǎn)的影響 [J].中醫(yī)研究, 2005, 19(4):11-14.
[11]孫萬森，王竹，王娟，等. 祛風(fēng)通絡(luò)方對(duì)大鼠系膜細(xì)胞增殖及轉(zhuǎn)化生長(zhǎng)因子-β1和白細(xì)胞介素-6 mRNA表達(dá)的影響 [J]. 中西醫(yī)結(jié)合學(xué)報(bào), 2008, 6(9):915-920.
