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醫(yī)學(xué)免費(fèi)論文:參麥注射液聯(lián)合綜合心理干預(yù)在非小細(xì)胞肺癌化療中
【摘要】 ［目的］觀察參麥注射液（SMI)聯(lián)合綜合心理干預(yù)在晚期非小細(xì)胞肺癌（NSCLC)化療中的使用價值。［方法］晚期NSCLC 79例，治療組40例，采用常規(guī)化療配合參麥注射液聯(lián)合綜合心理干預(yù)，并與單純化療的39例作對照，觀察兩組的體力狀況、療效、1年生存率、骨髓抑制情況等。［結(jié)果］治療組和對照組的Karnofsky評分提高+穩(wěn)定率為75.0%及46.2%、療效穩(wěn)定以上率（CR+PR+NC)為70.0%及46.2%,1年生存率為47.5%及25.6%。治療組與對照
組的Ⅱ度以上的白細(xì)胞下降的發(fā)生率分別為32.5%及53.8%（P=0.032)，Ⅱ度以上的血小板下降的發(fā)生率分別為30.0%及46.2%（P=0.032)，之間的差異均有統(tǒng)計學(xué)意義。［結(jié)論］治療組的Karnofsky評分、療效穩(wěn)定以上率、1年生存率、骨髓抑制發(fā)生率均優(yōu)于對照組，提示SMI及心理干預(yù)聯(lián)合化療治療晚期NSCLC有增效減毒作用。
【關(guān)鍵詞】 參麥注射液;非小細(xì)胞肺癌；綜合心理干預(yù);
The Role of Shenmai Injection Combined withPsychotherapy in Chemotherapy of Nonsmall Cell
Lung CancerNi Bingqiang，Zhang Zhihong，Wu Meijuan，et al
The Fifth Affiliated Hospital of GuangxiMedical College，Liuzhou（545006),China
Abstract：［Objective］To evaluate the efficacyof Shenmai injection combined with psychotherapy inchemotherapy of nonsmall cell lung cancer.［Method］79 cases of advanced nonsmall cell lungcancer were randomly divided into two groups，40cases in observation group with Shenmai injectioncombined with chemotherapy and psychotherapy，39cases in control group with chemotherapy alone.TheKarnofsky scores，therapeutic efficacy，one yearsurvival rate and incidence of myelosuppressionwere evaluated.［Result］ The two groups weresignificantly different in Karnofsky scores，therapeutic efficacy and one year survival rate.Theimprovement and stability rate of Karnofsky scoresand that of therapeutic efficacy were 75.0% and70.0% in observation group，with 46.2% and 46.2% incontrol group，respectively.One year survival ratewas 47.5% in observation group and 25.6% in controlgroup，respectively.The incidence ofmyelosuppression had significant differences in thetwo groups，with grade 2～4 leucopenia 32.5% inobservation group and 53.8% in control group（P=0.032)，with grade 2～3 thrombocytopenia 30.0%in observation group and 46.2% in control group（P=0.032).［Conclusion］ Combination treatment inobservation group was superior to the treatment incontrol group，with a higher Karnofsky scores，moreeffective therapy，a higher one year survival rateand a lower incidence of myelosuppression.Thetreatment of Shenmai injection combind withchemotherapy could reduce toxicity and enhancetherapeutic efficacy.
Key words: Shenmai injection（SMI);nonsmallcell lung cancer;psychotherapy;chemotherapy
Ⅲb、Ⅳ期非小細(xì)胞肺癌（NSCLC)化療的價值已得到肯定，但因其高癥狀負(fù)荷和高流失率等［1］，所以對癥中藥及心理干預(yù)等綜合治療仍占重要地位。我們采用參麥注射液（SMI)配合心理干預(yù)以期緩解癥狀，提高生存質(zhì)量，增加其對化療的依從性等，取得了較好效果，現(xiàn)報道如下醫(yī).學(xué).全.在.線gydjdsj.org.cn。
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