醫(yī)學(xué)論文范文:麥冬治療妊娠期糖尿病胰島素抵抗的作用及機(jī)制

醫(yī)學(xué)論文范文:麥冬治療妊娠期糖尿病胰島素抵抗的作用及機(jī)制

【摘要】  目的：觀察麥冬治療妊娠糖尿病胰島素抵抗的作用，研究其作用機(jī)制. 方法：選妊娠10 d大鼠，建立妊娠糖尿病胰島素抵抗動(dòng)物模型，正常大鼠為對(duì)照組，隨機(jī)將40只妊娠糖尿病胰島素抵抗大鼠分為4組（n=10)：GDM組、GDM＋麥冬組、GDM＋羅格列酮和GDM＋羅格列酮+麥冬組. 觀察用藥前后血糖、胰島素的變化，檢測(cè)腹腔脂肪組織中TNF�拨僚cleptin的mRNA表達(dá)變化. 結(jié)果：與對(duì)照組比較，GDM組大鼠空腹及餐后血糖與胰島素較正常對(duì)照組明顯升高（P<0.05)，TNF�拨僚cleptin的mRNA表達(dá)明顯增加（P<0.05)；與GDM組比較，麥冬治療組、羅格列酮治療組、羅格列酮+麥冬治療組大鼠空腹及餐后血糖均下降（P<0.05)，TNF�拨僚cleptin的mRNA表達(dá)明顯降低（P<0.05)；與麥冬治療組比較，羅格列酮治療組空腹及餐后血糖無(wú)明顯變化（P>0.05)，TNF�拨僚cleptin的mRNA表達(dá)無(wú)明顯變化（P>0.05)，羅格列酮+麥冬治療組空腹及餐后血糖明顯下降（P<0.01)，TNF�拨僚cleptin的mRNA表達(dá)明顯降低（P<0.05)；與羅格列酮組比較，羅格列酮+麥冬治療組空腹及餐后血糖明顯下降（P<0.01)，TNF�拨僚cleptin的mRNA表達(dá)明顯變化（P<0.05). 結(jié)論：麥冬治療妊娠期糖尿病療效明顯，能變胰島素抵抗?fàn)顟B(tài)，其機(jī)制與TNF�拨僚cleptin的mRNA表達(dá)的變化有關(guān)醫(yī).學(xué)全.在.線網(wǎng)站gydjdsj.org.cn.

【關(guān)鍵詞】  中藥;麥冬屬；妊娠期糖尿��；胰島素抵抗；腫瘤壞死因子α；瘦素

基金項(xiàng)目:廣東省中醫(yī)藥局資助項(xiàng)目(A2007128)

Treatment effect of Chinese herb Mai�瞕ong on gestational diabetes mellitus complicated by insulin resistance and its underlying mechanism

LI Rui�睲an1, QIN Jia�睯ia2, PEI Zhao�睭ui3

1Department of Obstetrics and Gynaecology, First Affiliated Hospital,  2Department of Obstetrics and Gynaecology of Tradi�瞭ional Chinese Medicine, Medical School, Jinan University, Guangzhou 510630, China,  3Department of Cardiology, First Affiliated Hospital, Sun Yat�瞫en University, Guangzhou 510080, China

【Abstract】 AIM: To investigate the treatment effect of Chinese herb Maidong on gestational diabetes  mellitus (GDM) and insulin resistance (IR) and to study its underlying mechanism. METHODS: GDM complicated by IR was induced in rats of 10 gestation days. Normal rats served as a control group. Forty model rats were randomized into GDM group, GDM & Maidong group, GDM & rosiglitazone maleate group, GDM, Maidong & rosiglitazone maleate group (n=10). Serum glucose and serum insulin were determined after and before administration. The expressions of TNF�拨� and leptin were detected in abdominal adipose tissues after and before administration. RESULTS: Compared to controls, serum glucose and serum insulin were evidently increased （P<0.05) and the expressions of TNF�拨� and leptin also significantly rose （P<0.05) in GDM group. Compared to GDM group, serum glucose and serum insulin were significantly decreased （P<0.05) and the expressions of TNF�拨� and leptin declined obviously, too （P<0.05) in GDM & Maidong group, GDM & rosiglitazone maleate group, GDM & Maidong & rosiglitazone maleate group. Compared to GDM & Maidong group, serum glucose and serum insulin remained unchanged （P>0.05)and the expressions of TNF�拨� and leptin were also unchanged （P>0.05) in rosiglitazone maleate group, while serum glucose, and serum insulin （P<0.01) and the expressions of TNF�拨� and leptin were signicantly reduced （P<0.05) in Maidong & rosiglitazone maleate group. Compared to rosiglitazone maleate group, serum glucose and serum insulin were significantly decreased （P<0.05) and the expressions of TNF�拨� and leptin were unchanged （P<0.05) in Maidong & rosiglitazone maleate group. CONCLUSION: Treatment effect of Chinese herb Maidong is good for GDM and can reverse IR. These actions are related to the changes of the contents of TNF�拨� and leptin.

【Keywords】 drugs, Chinese herb; ophiopogon; gestational diabetes mellitus (GDM); insulin resistance (IR); TNF�拨�; leptin

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