醫(yī)學(xué)論文范文:乙型肝炎病毒基因型檢測及其與肝功能的關(guān)系

醫(yī)學(xué)論文范文:乙型肝炎病毒基因型檢測及其與肝功能的關(guān)系

【摘要】 目的 探討乙型肝炎病毒基因型與肝功能的關(guān)系。方法 采用微板核酸分子雜交ELISA法檢測93例不同臨床類型的乙型肝炎患者的基因型并同時測定肝功能。結(jié)果 93例不同臨床類型乙型病毒性肝炎患者中，B型24例(25.81%)，C型59例(63.44%)，D型5例(5.38%)，混合型5例(B/D 3例，C/D 2例，占5.38%)。93例不同臨床類型的乙型肝炎患者中，以C基因型為主，其次為B基因型，部分以D型和混合型存在，無A、E、F型。按照慢性乙型肝炎、亞急性重型肝炎、肝硬化的順序，C基因型的檢出率逐漸增多，B基因型的檢出率逐漸減少。肝癌患者C基因型的檢出率沒有依次增高。C基因型各型乙型肝炎患者的ALT、AST、TBIL均高于B型，ALB低于B型，但差別無統(tǒng)計學(xué)意義。結(jié)論 西安地區(qū)病毒性肝炎以C基因型為主，部分以B、D及混合型存在，未發(fā)現(xiàn)A、E、F型。除肝癌外，C型的檢出率隨臨床類型的加重而增多。

【關(guān)鍵詞】 乙型肝炎病毒;基因型;微板核酸分子雜交;肝功能

Detection of hepatitis B virus genotype and the relationship between　hepatitis B virus genotype and the function of liver

ZHU Feng�瞦un, HUO Kang, LI Chun�瞛i, DI Peng�瞔hao

Department of Infectious Diseases, the First Affiliated Hospital,Medical School of Xi�餫n Jiaotong University, Xi�餫n 710061, China醫(yī).學(xué)全.在.線網(wǎng)站gydjdsj.org.cn

ABSTRACT: Objective To investigate the relationship between hepatitis B virus (HBV) genotype and liver function. Methods The method of microboard nucleate molecular hybridization was employed to detect the genotype in 93 HBV patients of different clinical types and the function of liver. Results Among the 93 HBV patients of different clinical types, there were 24 cases of genotype B (25.81%), 59 cases of genotype C (63.44%), 5 cases of genotype D (5.38%), and 5 cases of mixed type (3 cases of B/D, 2 cases of C/D, 5.38%). Therefore, genotype C took up the largest proportion, followed by genotype B, and then D and mixed genotypes, but there was no genotype A, E or F. The detection rate of genotype C increased according to the sequence of chronic hepatitis B, subacute severe hepatitis and hepatocirrhosis while the detection rate of genotype B decreased gradually. However, the detection rate of genotype C in hepatocellar carcinoma did not rise correspondingly. The levels of ALT, AST and TBIL of genotype C were higher than those of genotype B, but the level of ALB in genotype C was lower than that of genotype B. None of the differences had significance. Conclusion Most of HBV genotypes in Xi�餫n were C, some of them were B, D and mixed genotypes, but no genotype A, E or F was detected. Except hepatocellar carcinoma, the detection rate of genotype C rose according to the severity of clinical type.

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