醫(yī)學論文范文:阿加曲班對大鼠肢體缺血再灌注損傷血液流變學指標影響的實驗研究

本研究通過肢體缺血�苍俟嘧�損傷的動物實驗表明，阿加曲班可以有效改善肢體缺血�苍俟嘧⒑蟮难�液流變學異常。分析原因主要有以下2點：(1)降低血漿P�策x擇素和ICAM��1濃度，減少白細胞粘附，從而減輕全身炎性反應。(2)直接滅活凝血酶(因子Ⅱa)的活性，避免進一步促進凝血作用的級聯(lián)反應,防止微血栓形成。綜上所述阿加曲班表現(xiàn)出對缺血�苍俟嘧�損傷的保護作用。

【參考文獻】

1 孫君志，蘇全生.骨骼肌缺血再灌注損傷機制及其防治進展.四川體育科學,2006，12：46��50.

2 戚偉，陳克俊，闞世廉，等.缺血后處理對大鼠骨骼肌缺血再灌注損傷的影響.中華手外科雜志,2009,25:121��123.

3 張子彥.阿加曲班研究進展.國際內(nèi)科學雜志,2007,34:483��485.

4 Hitosugi M,Niwa M,Takatsu A.Changes in blood viscosity by heparin and argatroban. Thromb Res, 2001,104:371��374.

5 符慶瑛,李著華,張艷青，等.兔腎缺血再灌注損傷時腸系膜微循環(huán)和血液流變性變化及PGI��2的影響. 中國血液流變學雜志,2004,14:25��29.

6 張鋼，高玨琪.急性缺氧對大鼠腸系膜微循環(huán)白細胞流變學行為的影響.第三軍醫(yī)大學學報,2002,24:320��322.

7 楊愛軍.缺血�苍俟嘧�損傷機制的研究進展.局解手術(shù)學雜志,1998,7181��7183.

8 Strieter RM, Kunkel SL. Acute lung injury: the role of cytokines in the elicitation of neutrophils. J Invest Med,1994,42:640��651.

9 Senden NH, Jeunhomme TM, Heemskerk JW, et al. Factor Xa induces cytokine production and expressionof adhesion molecules by human umbilical vein endothelial cells. J Immunol, 1998,161:4318��4324.

10 Kaplanski G, Marin V, Fabrigoule M,et al.Thrombin�瞐ctivated human endothelial cells support monocyte adhesion in vitro following expression of intercellular adhesion molecule��1 (ICAM��1; CD54) and vascular cell adhesion molecule��1 (VCAM��1; CD106). Blood,1998,92:1259��1267醫(yī).學全.在.線網(wǎng)站gydjdsj.org.cn.

11 Kaur J, Woodman RC, Ostrovsky L, et al. Selective recruitment of neutrophils and lymphocytes by thrombin: a role for NF�瞜appaB. Am J Physiol Heart Circ Physiol,2001,281:H784�睭795.

12 Yamaguchi Y, Okabe K, Liang J,et al. Thrombin and factor Xa enhance neutrophil chemoattractant production after ischemia/reperfusionin the rat liver.J Surg Res,2000,92:96��102.

13 Shinohara T, Suzuki K, Takada K,et al. Regulation of proteinase�瞐ctivated receptor 1 by inflammatory mediators in human vascular endothelial cells.Cytokine,2002,19: 66��75.

14 羅承鋒.阿加曲班的藥理作用與臨床應用.血栓與止血學,2007,13:185��192.

15 Hitosugi M, Niwa M, Takatsu A. Changes in blood viscosity by heparin and argatroban. Thromb Res, 2001,104:371��374.

上一頁  [1] [2] [3] [4]  下一頁