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四川省抗癌協(xié)會(huì)常務(wù)理事、 四川省誘變學(xué)會(huì)理事、 四川省預(yù)防醫(yī)學(xué)會(huì)毒理學(xué)專業(yè)委員會(huì)委員、 《腫瘤預(yù)防與治療》常務(wù)編委 | |
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1 腫瘤干細(xì)胞生物學(xué)分離、鑒定實(shí)體瘤的腫瘤干細(xì)胞，建立腫瘤干細(xì)胞的體內(nèi)、外實(shí)驗(yàn)?zāi)Ｐ停芯磕[瘤干細(xì)胞與其相應(yīng)的腫瘤細(xì)胞、正常干細(xì)胞生物學(xué)特性的異同，以期探索靶向腫瘤干細(xì)胞的根治措施。 2 老化與腫瘤建立老化與腫瘤的動(dòng)物模型，尤其是大動(dòng)物模型gydjdsj.org.cn，研究老化、腫瘤的病因?qū)W因素及發(fā)生機(jī)理，老化與腫瘤的關(guān)系及防治基礎(chǔ)。 3 抗氧化、抗衰老、抗腫瘤新藥及作用機(jī)理利用老化與腫瘤的動(dòng)物模型，結(jié)合現(xiàn)有工作基礎(chǔ)，研究抗氧化、抗衰老、抗腫瘤新藥及作用機(jī)理。 | |
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承擔(dān)科研項(xiàng)目情況（負(fù)責(zé)人) 1國(guó)家自然科學(xué)基金項(xiàng)目：靶向缺氧信號(hào)通路誘導(dǎo)膠質(zhì)瘤干細(xì)胞分化及其機(jī)制研究（批準(zhǔn)號(hào): 31071197) 2 國(guó)家自然科學(xué)基金項(xiàng)目：腦腫瘤干細(xì)胞生物學(xué)特性研究（批準(zhǔn)號(hào): 30471779) 3 國(guó)家教育部博士點(diǎn)基金：力電刺激對(duì)骨骼肌衛(wèi)星細(xì)胞向心肌細(xì)胞分化的影響（批準(zhǔn)號(hào): 20060610059) 4四川省科技廳公關(guān)項(xiàng)目：靶向腫瘤干細(xì)胞治療乳腺癌的實(shí)驗(yàn)研究（批號(hào):2008SG0016) 5四川省衛(wèi)生廳科研課題: 共軛三烯酸抗乳腺癌作用的實(shí)驗(yàn)研究（批準(zhǔn)號(hào):090316)獲獎(jiǎng)與專利 1 2002年獲四川省科技進(jìn)步二等獎(jiǎng)“丹參酮抗腫瘤作用及其機(jī)理的研究”，排名第二 2 2002年獲成都市科技進(jìn)步二等獎(jiǎng)“丹參酮抗腫瘤作用及其機(jī)理的研究”，排名第二 3 2003年國(guó)家發(fā)明專利授權(quán)“丹參酮在制備治療腫瘤藥物中應(yīng)用”（ZL9912 14609，)主研 4 2008年國(guó)家發(fā)明專利授權(quán)“荔枝果皮提取物及其制備方法和用途”（ZL2004 10022559.0)負(fù)責(zé)人 | |
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1 Zhang T, Gao Y, Mao Y, Zhang Q, Lin C, Lin P, Zhang J, Wang X*. Growth inhibition and apoptotic effect of alpha-eleostearic acid on human breast cancer cells. Nat Med. 2011 Jun 21. [Epub ahead of print] |
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2 Zhang QB, Gao YP, He JT, Zhang TT, Lin P, Zhang J, Wang XJ*. Establishment of a novel human esophageal squamous cell carcinoma cell line (ESC-410) and its partial biological characterization. Dis Esophagus.2011 24(2):120-126.
3. Wang J, Wang X*, Jiang S, Lin P, Zhang J, Wu Y, Xiong Z, Ren JJ, Yang H. Partial biological characterization of cancer stem-like cell Line (WJ2) of human glioblastoma multiforme. Cell Mol Neurobiol. 2008 ;28(7):991-1003.
4. Liu JM, Mao BY, Hong S, Liu YH, Wang XJ*. The postoperative brain tumour stem cell (BTSC) niche and cancer recurrence. Adv Ther. 2008;25(5):389-98.
5. Wang J, Wang X*, Jiang S, Lin P, Zhang J, Lu Y, Wang Q, Xiong Z, Wu Y, Ren J, Yang H. Cytotoxicity of fig fruit latex against human cancer cells. Food Chem Toxicol. 2008；46：1025-1033.
6. Wang J, Wang X*, Jiang S, Lin P, Zhang J, Wu Y, Xiong Z, Ren JJ, Yang H. Establishment of a New Human Glioblastoma Multiforme Cell Line (WJ1) and Its Partial Characterization. Cell Mol Neurobiol. 2007; 27(7): 831-843.
7. Wang J, Wang X*, Jiang S, Yuan S, Lin P, Zhang J, Lu Y, Wang Q, Xiong Z, Wu Y, Ren J, Yang H. Growth gydjdsj.org.cn inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells. J Neurooncol. 2007; 82 (1): 11-21.
8. Wang X*, Wei Y, Yuan S, Liu G, Zhang J, Wang W. Potential anticancer activity of litchi
fruit pericarp extract against hepatocellular carcinoma in vitro and in vivo. Cancer Lett. 2006; 239(1): 144-150.
9. Wang X*, Yuan S, Wang J, Lin P, Liu G, Lu Y, Zhang J, Wang W, Wei Y. Anticancer activity of litchi fruit pericarp extract against human breast cancer in vitro and in vivo. Toxicol Appl Pharmacol. 2006; 215(2): 168-178.
10. Wang X*, Wei Y, Yuan S, Liu G, Lu Y, Zhang J, Wang W. Potential anticancer activity of tanshinone IIA against human breast cancer. Int J Cancer. 2005; 116 (5): 799-807.
11. Wang XJ*, Yuan SL, Lu Q, Lu YR, Zhang J, Liu Y, Wang WD. Potential involvement of leptin in carcinogenesis of hepatocellular carcinoma. World J Gastroenterol. 2004; 10(17):2478-2481..
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