孫玉潔，博士，特聘教授，博士生導(dǎo)師
細(xì)胞生物學(xué)與醫(yī)學(xué)遺傳學(xué)系主任
研究方向：B細(xì)胞淋巴瘤形成的分子生物學(xué)機(jī)制
地址：南京市漢中路140號(hào)細(xì)胞生物學(xué)與醫(yī)學(xué)遺傳學(xué)系
郵編：210029
電話：025-86862731
E-mail:yujiesun@njmu.edu.cn
醫(yī)學(xué)全在.線gydjdsj.org.cn
孫玉潔，女, 特聘教授，博士生導(dǎo)師, 1984年獲武漢同濟(jì)醫(yī)科大學(xué)醫(yī)學(xué)遺傳專業(yè)碩士學(xué)位，同年進(jìn)入南京醫(yī)科大學(xué)任教，1991年赴德國(guó)維爾茨堡大學(xué)攻讀博士學(xué)位，1996年9月獲人類遺傳學(xué)博士學(xué)位。 1996年10月赴美國(guó)洛杉磯City of Hope National Medical Center分子醫(yī)學(xué)系工作，重點(diǎn)研究染色體易位、原癌基因激活及B細(xì)胞巴瘤形成間的關(guān)系及其分子生物學(xué)機(jī)制。2003年元月回國(guó)工作，被南京醫(yī)科大學(xué)聘為特聘教授和博士生導(dǎo)師, 細(xì)胞生物學(xué)和醫(yī)學(xué)遺傳學(xué)系主任及學(xué)科帶頭人。 目前主持承擔(dān)國(guó)家自然科學(xué)基金、江蘇省重點(diǎn)招標(biāo)項(xiàng)和江蘇省衛(wèi)生廳科研項(xiàng)目各一項(xiàng)，已招收博士后兩人、博士生6人，碩士研究生6人。主要研究方向：（1)BCL2原癌基因調(diào)控的分子生物學(xué)機(jī)制極其在腫瘤發(fā)生和發(fā)展中的作用；（2)尋找乳腺癌和大腸癌轉(zhuǎn)移過(guò)程的生物標(biāo)志物（3)用基因工程的方法結(jié)合動(dòng)物模型篩選和研發(fā)抗腫瘤藥物。
Main Publications (2001-2007)
1．Changyan Ma, Jingjing Zhang, Linda K Durrin. Jinghuan Lv, Dongya Zhu Xiao Han, and Sun Y.（2007). The BCL2 major breakpoint region (mbr) regulates gene expression. Oncogene 19; 26 (18): 2649-57 [Epub 2006 Oct 23].
2. Zhang JJ， Ma CY, Han X,Durrin L, and Sun Y.(2006). The BCL2 major breakpoint region (mbr) possesses transcriptional regulatory function. Gene 379：127-131.
3. Men Z, Sun J, Ling J, Lv J, Zhu DY, Chen Q, Sun Y* and Han X*. (2006) Prostaglandin E2 regulates Foxo activity via the Akt pathway: implications for pancreatic islat beta-cell dysfunction. Diabetologia Oct 11 [Epub ahead of print]. *Co-corresponding authors.
4. Sun Y, Wang T, Yin Y, Xu S, Ma C, Han X. (2006). The behavior of SATB1, a MAR binding protein, in response to apoptosis stimulation. Cell Biology International. 30(3):244-247.
5. Wang Z, Lv JH, Zhang RH, ZyX, Sun Y*, Zhu J, Han X*. (2006). Co-culture with fat cells induces insulin resistance in primary hepatocytes. BBRC 345 (3):976-83. *Co-corresponding authors.
6. Lin J, Sun Y, Zhu D, Chen Q and Han X. Potential role of NO in modulation of COX-2 expression and PGE2 production in pancreatic β-cells. (2005). Acta Biochimica et Biophysica Sinica 37(2):139-146.
7. Sun Y, Durrin, LK, Krontiris TG. (2003). Specific interaction of PML bodies with the TP53 locus in Jurkat Interphase Nuclei. Genomics 82(2):250-258.
8. Sun Y, Wyatt RT, Bigley A, Krontiris TG. (2001). Expression and replication timing patterns of wild type and translocated BCL2 genes. Genomics 73(2): 161-170.
9. Sun Y. and Han X. (2001). Detection of the specific translocation of BCL2 gene with immunofluorescence in situ hybridization (FISH) method in interphase nuclei. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 6: 472-475.
10. Han X, Sun Y, Stephen Scott, and David Bleich. (2001). Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and b-cells. Diabetes. 50(5): 1047-55.
11. Han X, Chen S, Sun Y, Jerry L. Nadler, and Bleich D. (2002). Induction of cyclooxygenase-2 (COX-2) gene in pancreatic beta cells by 12-lipoxygenase pathway product 12-hydroxyeicosatetraenoic acid (12-HETE). Molecular Endocrinology. 19: 2145-2154.
