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醫(yī)學(xué)免費論文:TACE、PEI雙介入間隔療法治療晚期原發(fā)性肝細(xì)胞癌臨床觀察
【摘要】 目的 對照觀察肝動脈化療栓塞(transcatheter arterial chemoembolization，TACE)和經(jīng)皮肝穿刺無水乙醇注射(percutaneous ethanol injection，PEI)雙介入間隔療法治療晚期原發(fā)性肝細(xì)胞癌(hepatocellular carcinoma，HCC)臨床效果。方法 觀察組25例采用間隔2周進(jìn)行TACE、PEI分別配合治療，每療程TACE 2～3次、PEI 2～4次。對照組29例單純進(jìn)行TACE治療。兩組觀察期3年。結(jié)果 觀察組1年內(nèi)生存率與對照組相比無明顯差異，2年、3年內(nèi)生存率高于對照組(P<0.05)；觀察組腫瘤縮小總有效率高于對照組(P<0.05)。結(jié)論 TACE、PEI間隔雙介入療法較單純TACE治療晚期原發(fā)性肝細(xì)胞癌能夠提高治療效果，延長患者存活時間，改善生存質(zhì)量。
【關(guān)鍵詞】 原發(fā)性肝細(xì)胞癌； 肝動脈化療栓塞術(shù)； 經(jīng)皮肝穿刺無水乙醇注射
Clinical observation of treating the primary hepatocellular carcinoma in the advanced stage by using TACE and PEI ZHONG Liqing,XU yincong,LU longhui,et al.Department of Xray,the 123rd Hospital of PLA,Bengbu 233015,China醫(yī).學(xué).全.在.線gydjdsj.org.cn
【Abstract】 Objective To comparatively observe the clinical efficacy of transcatheter arterial chemoembolization(TACE) combined with percutaneous ethanol injection (PEI)in the treatment of primary hepatocellular carcinoma (HCC) in the advanced stage. Methods The observation group (25 cases) were treated with TACE and PEI with intervals about two weeks. Each course of treatment included 2 to 3 times of TACE and 2 to 4 times of PEI.The control group (29 cases) were treated only with TACE. All the two groups were observed for 3 years. Results The survival rate of the two groups had no remarkable difference in one year, but the survival rate of observation group was higher than that of the control group in two or three years(P<0.05).The total effective rate of tumor reduction in the observation group was higher than that of the control group(P<0.05). Conclusion Compared with the single TACE treatment, TACE combined with PEI treatment for the advanced primary HCC can improve the therapeutic efficacy and extend the survival time and improve the quality of life of patients.
【Key words】 Primary hepatocellular carcinoma；Transcatheter arterial chemoembolization；Percutaneous ethanol injection
對于不能手術(shù)切除的晚期原發(fā)性肝細(xì)胞癌(hepatocellular carcinoma ,HCC)，目前采用的姑息療法是肝動脈化療栓塞(transcatheter arterial chemoembolization，TACE)和經(jīng)皮肝穿刺無水乙醇注射(percutaneous ethanol injection，PEI)。我院采用TACE、PEI間隔療法治療HCC患者25例，取得較好療效。
