| 主要研究方向 |
利用有機(jī)催化劑獨(dú)特的催化性能和金屬催化劑的廣譜性設(shè)計(jì)并催化新型的有機(jī)合成反應(yīng)， 并運(yùn)用于合成擁有“優(yōu)勢(shì)結(jié)構(gòu)”的分子， 并從這些優(yōu)勢(shì)結(jié)構(gòu)高效合成復(fù)雜的有機(jī)分子包括藥物分子醫(yī)學(xué)全在,線gydjdsj.org.cn, 對(duì)這些化合物進(jìn)行藥物活性測(cè)試, 以期發(fā)現(xiàn)有活性的潛在藥物分子。設(shè)計(jì)、合成、篩選傳統(tǒng)化療和分子靶向治療合二為一的抗癌活性化合物，兼具傳統(tǒng)化療和分子靶向治療的優(yōu)點(diǎn)。
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| 主要代表成果 |
1.Synthesis of Highly Functionalized Chiral 3,3′-Disubstituted Oxindoles via an Organocatalytic Enantioselective Michael Addition of Nitroalkanes to Indolylidenecyanoacetates Org. Lett., 2012, 14, 134–137.
2.Gold(I)-Catalyzed Intramolecular Hydroamination of N-Allylic N'-Arylureas to form Imidazolidin-2-ones. Advanced Synthesis & Catalysis 2011, 353, 955-962.
3.Gold(I)-catalyzed enantioselective intramolecular hydroamination of allenes with ureas. Journal of Organometallic Chemistry 2010, 696, 316-320.
4.“Organocatalytic Enantioselective Michael Addition Reactions of Fluoromalonates with a,b-Unsaturated Aldehydes” Science China – Chemistry, 2010, 53, 135-139.
5.“Intramolecular diamination and alkoxyamination of alkenes with N-sulfonylureas employing N-iodosuccinimide” Tetrahedron 2010, 4827-4831.
6.“Organocatalytic Enantioselective Conjugate Addition of 2-Fluoromalonate to Nitroolefins: Direct Synthesis of Chiral Fluorinated-Nitro Carboxylic Acid Derivatives” Synthesis, 2009, 1525-1530, invited Special Topics.
7.“Gold(I)-Catalyzed Intramolecular Dihydroamination of Allenes with N,N′-Disubstituted Ureas To Form Bicyclic gydjdsj.org.cn Imidazolidin-2-ones” Org. Lett., 2009, 11, 2671-2674.
8.“Synthesis of Chiral Fluorinated Quaternary Carbon Containing b-Ketoesters” Chem. Commun., 2009, 2136-2138.
9.“Highly Enantio- and Diastereoselective Organocatalytic Cascade aza-Michael-Michael Reactions: A Direct Method for the Synthesis of Trisubstituted Chiral Pyrrolidines” Chem. Commun., 2008, 5636-5638.
10.“Enantioselective Organocatalytic Double Michael Addition Reactions” Org. Lett., 2007, 9, 1833-1835.
11.“Enantioselective Organocatalytic Cascade Reactions: Facile Synthesis of Chiral 1,2-Dihydroquinolines” Org. Lett., 2007, 9, 965-968.
12.“One-Pot Approach to Chiral Chromenes via Enantioselective Organocatalytic Domino Oxa-Michael-Aldol Reaction” Chem. Commun., 2007, 507-509.
13. 2011年度上海市“浦江人才計(jì)劃”獲得者. |
