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孫玉潔，博士，特聘教授，博士生導師
細胞生物學與醫(yī)學遺傳學系主任
研究方向：B細胞淋巴瘤形成的分子生物學機制
地址：南京市漢中路140號細胞生物學與醫(yī)學遺傳學系
郵編：210029
電話：025-86862731
E-mail:yujiesun@njmu.edu.cn
醫(yī)學全在.線gydjdsj.org.cn
孫玉潔，女, 特聘教授，博士生導師, 1984年獲武漢同濟醫(yī)科大學醫(yī)學遺傳專業(yè)碩士學位，同年進入南京醫(yī)科大學任教，1991年赴德國維爾茨堡大學攻讀博士學位，1996年9月獲人類遺傳學博士學位。 1996年10月赴美國洛杉磯City of Hope National Medical Center分子醫(yī)學系工作，重點研究染色體易位、原癌基因激活及B細胞巴瘤形成間的關(guān)系及其分子生物學機制。2003年元月回國工作，被南京醫(yī)科大學聘為特聘教授和博士生導師, 細胞生物學和醫(yī)學遺傳學系主任及學科帶頭人。 目前主持承擔國家自然科學基金、江蘇省重點招標項和江蘇省衛(wèi)生廳科研項目各一項，已招收博士后兩人、博士生6人，碩士研究生6人。主要研究方向：（1）BCL2原癌基因調(diào)控的分子生物學機制極其在腫瘤發(fā)生和發(fā)展中的作用；（2）尋找乳腺癌和大腸癌轉(zhuǎn)移過程的生物標志物（3）用基因工程的方法結(jié)合動物模型篩選和研發(fā)抗腫瘤藥物。
Main Publications (2001-2007)
1．Changyan Ma, Jingjing Zhang, Linda K Durrin. Jinghuan Lv, Dongya Zhu Xiao Han, and Sun Y.（2007). The BCL2 major breakpoint region (mbr) regulates gene expression. Oncogene 19; 26 (18): 2649-57 [Epub 2006 Oct 23].
2. Zhang JJ， Ma CY, Han X,Durrin L, and Sun Y.(2006). The BCL2 major breakpoint region (mbr) possesses transcriptional regulatory function. Gene 379：127-131.
3. Men Z, Sun J, Ling J, Lv J, Zhu DY, Chen Q, Sun Y* and Han X*. (2006) Prostaglandin E2 regulates Foxo activity via the Akt pathway: implications for pancreatic islat beta-cell dysfunction. Diabetologia Oct 11 [Epub ahead of print]. *Co-corresponding authors.
4. Sun Y, Wang T, Yin Y, Xu S, Ma C, Han X. (2006). The behavior of SATB1, a MAR binding protein, in response to apoptosis stimulation. Cell Biology International. 30(3):244-247.
5. Wang Z, Lv JH, Zhang RH, ZyX, Sun Y*, Zhu J, Han X*. (2006). Co-culture with fat cells induces insulin resistance in primary hepatocytes. BBRC 345 (3):976-83. *Co-corresponding authors.
6. Lin J, Sun Y, Zhu D, Chen Q and Han X. Potential role of NO in modulation of COX-2 expression and PGE2 production in pancreatic β-cells. (2005). Acta Biochimica et Biophysica Sinica 37(2):139-146.
7. Sun Y, Durrin, LK, Krontiris TG. (2003). Specific interaction of PML bodies with the TP53 locus in Jurkat Interphase Nuclei. Genomics 82(2):250-258.
8. Sun Y, Wyatt RT, Bigley A, Krontiris TG. (2001). Expression and replication timing patterns of wild type and translocated BCL2 genes. Genomics 73(2): 161-170.
9. Sun Y. and Han X. (2001). Detection of the specific translocation of BCL2 gene with immunofluorescence in situ hybridization (FISH) method in interphase nuclei. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 6: 472-475.
10. Han X, Sun Y, Stephen Scott, and David Bleich. (2001). Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and b-cells. Diabetes. 50(5): 1047-55.
11. Han X, Chen S, Sun Y, Jerry L. Nadler, and Bleich D. (2002). Induction of cyclooxygenase-2 (COX-2) gene in pancreatic beta cells by 12-lipoxygenase pathway product 12-hydroxyeicosatetraenoic acid (12-HETE). Molecular Endocrinology. 19: 2145-2154.
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