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業(yè)績(jī)一覽：
一、發(fā)表文章:
1.Yang, J. and Duerksen-Hughes, P. (1998) A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage. Carcinogenesis, 19, 1117-1125
2.Duerksen-Hughes, P., Yang, J., and Oczan, O. (1999) p53 induction as a genotoxic test for twenty-five chemicals undergoing in vivo carcinogenicity testing. Env. Health
Persp., 107, 805-812
3.Duerksen-Hughes, P., Yang, J., and Schwartz, S. (1999) HPV 16 E6 blocks TNF-mediated apoptosis in mouse fibroblast LM cells. Virology, 264, 55-65
4.Yang, J. and Duerksen-Hughes, P. (2001) Activation of a p53 independent, sphingolipid-mediated cytolytic pathway in p53-negative mouse fibroblast cells treated with N-methyl-N-nitro-N-nitrosoguanidine. J. Biol. Chem., 276, 27129-27135
5.Yang, J.*, Hooper, W. C., Phillips, D., and Talkington, D. (2002) Regulation of proinflammatory cytokines in human lung epithelial cells during Mycoplasma pneumoniae infection. Infect. Immun., 70, 3649-3655.
6.Yang, J., Hooper, W. C., Phillips, D., Tondella, M., and Talkington, D. (2002) Centrifugation of human lung epithelial carcinoma A549 cells up-regulates interleukin-1beta gene expression. Clin. Diagn. Lab. Immunol. 9, 1142-1143.
7.Yang, J., Hooper, W. C., Phillips, D., Tondella, M., and Talkington, D. (2003) Induction of proinflammatory cytokines in human lung epithelial cells during Chlamydia pneumoniae infection. Infect. Immun. 71, 614-620.
8.Yang, J., Hooper, W. C., Phillips, D., and Talkington, D. (2003) Interleukin-1beta responses to Mycoplasma pneumoniae infection are cell-type specific. Microbial Pathog., 34, 17-25.
9.Yang, J., Yu, Y., and Duerksen-Hughes, P. (2003) Protein kinases and their involvement in the cellular responses to genotoxic stress. Mutat. Res.-Rev. Mutat. Res., 543, 31-58.
10.Zhu, F., Jin, C., Song, T., Yang, J., Guo, L., Yu, Y. (2003) Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N’-nitro-N-nitrosoguanidine and its role in mutagenesis. World J. Gastroentol. 9, 888-893.
11.Jin, J., Gao, Z., Guo, L., Yang, J., and Yu, Y. (2003) Altered expression of zinc finger proteins, ADAMs, and integrin-related proteins following treatment of cultured human cells with a low concentration of N-methyl-N'-nitro-N-nitrosoguanidine. Environ. Mol. Mutagen. 41, 344-352.
12.Wang, Z., Wang, G., Yang, J., Guo, L., and Yu, Y. (2003) Activation of Protein Kinase A and Clustering of Cell Surface Receptors by N-methyl-N'-nitro-N-nitrosoguanidine are Independent of Genomic DNA damage. Mutat. Res. 528, 29-36.
13.Yang, J., Yu, Y., Hamrick, H. E., and Duerksen-Hughes, P. (2003) ATM, ATR, and DNA-PK: Initiators of cellular genotoxic stress response. Carcinogenesis, 24, 1571-1580.
14.Yang, J., Xu, Z., Huang, Y., Hamrick, H., Duerksen-Hughes, P., and Yu, Y. (2004) ATM and ATR: sensing DNA damage. World J. Gastroenterol. 10, 155-160.
15.Jin, J., Yang, J., Gao, Z., and Yu, Y. (2004) Proteomic Analysis of Cellular Responses to Low Concentration N-methyl-N’-nitro-N-nitrosoguanidine in human amnion FL cells. Environ. Mol. Mutagen. 43, 93-99.
16.Gao, Z., Jin, J., Yang, J., and Yu, Y. (2004) Zinc finger proteins and other transcription regulators as response proteins in benzo(a)pyrene exposed cells. Mutat. Res. 550, 11-24.
17.Yu, Y., Yang, J., Zhu, F., and Xu, F. (2004) Response of REV3 promoter to N-methyl-N-nitro-N-nitrosoguanidine. Mutat. Res., 550, 49-58.
18.Yang, J., Yu, Y., Sun, S., Duerksen-Hughes, P. (2004) Ceramide and other sphingolipids in cellular response. Cell Biochem. Biophys., 40, 323-350.
19.Yang, J., Phillips, D., Hooper, W. C., and Talkington, D. F. (2004) Cytokines in Mycoplasma pneumoniae infections. Cytokine Grow. Factor. Rev., 15, 157-168.
20.Shi, B., Cai, Z., Yang, J., and Yu, Y. (2004) N-methyl-N-nitro-N- nitrosoguanidine sensitivity, Mutator phenotype and Sequence specificity of spontaneous mutagenesis in FEN-1 deficient cells. Mutat. Res., 556, 1-9.
21.Gao, Z., Yang, J., Huang, Y., and Yu, Y. (2005) N-methyl-N-nitro-N-nitrosoguanidine interferes with the epidermal growth factor receptor-mediated signaling pathway. Mutat. Res., 570, 175-184.
22.Huang, Y., Yang, J.*, Shen, J., Chen, F., and Yu, Y. (2005) Sphingolipids are involved in N-methyl-N-nitro-N-nitrosoguanidine-induced epidermal growth factor clustering. Biochem. Biophys. Res. Commun., 330, 430-438.
23.Huang, Y., Shen, J., Wang, T., Chen, F., Yu, Y., and Yang, J.* (2005) A lipidomic study of the effects of N-methyl-N’-nitro-N-nitrosoguanidine on sphingomyelin metabolism. Acta Biochim Biophys Sinica, 37, 515-524.
24.Zhou, C., Li, Z., Diao, H., Yu, Y., Zhu, W., Dai, Y., Chen, F.F., and Yang, J.* (2006) DNA damage evaluated by H2AX foci formation by a selective group of chemical/physical stressors. Mutat. Res., 604, 8-18.
25.Yu, Y., Zhu, W., Diao, H., Zhou, C., Chen, F.F., and Yang, J.* (2006) A comparative study of using comet assay and H2AX foci formation in the detection of N-methyl-N’-nitro-N-nitrosoguanidine. Toxicology in Vitro, 20, 959-965.
26.Luo, Q., Yang, J., Zeng, Q., Zhu, X., Qian, Y., and Huang, H. (2006) 50 Hz Electromagnetic Fields Induce gammaH2AX Foci Formation in Mouse Preimplantation Embryos in vitro. Biol. Reproduction, Published on July 19, 2006 as DOI:10.1095/biolreprod.106.052241
27.Li, Z., Yang, J.#, and Huang, H. (2006) Oxidative stress induces H2AX phosphorylation in human spermatozoa. FEBS Lett., In press.
28.Li, Z., Yang, J., and Huang, H. (2006) Adriamycin induces H2AX phosphorylation in human spermatozoa. Biol. Reproduction, In revision.
29.余應(yīng)年，楊軍. 化學(xué)誘變劑誘發(fā)基因非定標(biāo)性突變的分子機(jī)理研究. 浙江大學(xué)學(xué)報(bào)醫(yī)學(xué)版, 2003, 32:369-374.
30.金靜華，高志華，楊軍，余應(yīng)年. 低濃度MNNG誘發(fā)FL細(xì)胞應(yīng)答反應(yīng)的蛋白組學(xué)研究. 浙江大學(xué)學(xué)報(bào)醫(yī)學(xué)版, 2003, 32:375-379.
31.高志華，金靜華，楊軍，余應(yīng)年. 苯并[a]芘誘導(dǎo)的FL細(xì)胞鋅指蛋白等表達(dá)的改變. 浙江大學(xué)學(xué)報(bào)醫(yī)學(xué)版, 2003, 32:380-384.
32.王政，王谷亮，楊軍，余應(yīng)年. 低濃度MNNG誘發(fā)非DNA損傷依賴的細(xì)胞信號(hào)通路. 浙江大學(xué)學(xué)報(bào)醫(yī)學(xué)版, 2003, 32:385-389.
33.王谷亮，王政，楊軍，余應(yīng)年. 低濃度MNNG激活轉(zhuǎn)錄因子. 浙江大學(xué)學(xué)報(bào)醫(yī)學(xué)版, 2003, 32:390-392.
34.朱峰，楊軍，徐方，余應(yīng)年. 人REV3基因啟動(dòng)子區(qū)的克隆和生物信息學(xué)分析及其對(duì)MNNG的反應(yīng). 浙江大學(xué)學(xué)報(bào)醫(yī)學(xué)版, 2003, 32:393-397.
35.羅月球，楊軍，余應(yīng)年. POLH基因反義阻斷細(xì)胞系的建立及POLH在MNNG引起的非定標(biāo)性突變中的作用. 浙江大學(xué)學(xué)報(bào)醫(yī)學(xué)版, 2003, 32:398-402.
36.黃韻，石為，呂麗華，余應(yīng)年, 楊軍*. 細(xì)胞DNA損傷應(yīng)激反應(yīng)中絲裂原活化蛋白激酶的信號(hào)通路. 國外醫(yī)學(xué)（生理、病理科學(xué)與臨床分冊(cè)）, 2004, 24:438-441.
37.黃韻，余應(yīng)年，楊軍*. 鞘脂類研究的進(jìn)展. 浙江大學(xué)學(xué)報(bào)醫(yī)學(xué)版, 2005, 34, 375-378.
38.余艷柯，陸源，余應(yīng)年，楊軍*. -H2AX: DNA雙鏈損傷的標(biāo)志. 中國藥理學(xué)與毒理學(xué)雜志, 2005, 19, 237-240.
39.沈靜，楊軍，余應(yīng)年. 質(zhì)譜在蛋白組學(xué)中的應(yīng)用. 中國病理生理雜志, 2005, 21, 2057-2061.
40.刁匯鈴，周春仙，余艷柯，楊軍*. 2－乙酰氨基芴誘導(dǎo)H2AX焦點(diǎn)的形成. 中國藥理學(xué)與毒理學(xué)雜志，2006, 20, 131-137.
41.錢俊斌，錢聰，葛朝榮，楊軍*. 杭州市自然水體中細(xì)菌耐藥性分析. 浙江預(yù)防醫(yī)學(xué)，2006, 18, 36-37.
42.周新妹，姚慧，夏滿莉，曹春梅，蔣惠娣，夏強(qiáng)，楊軍. 蘆丁對(duì)離體大鼠主動(dòng)脈環(huán)的舒張作用及相關(guān)機(jī)制. 中國藥學(xué)雜志，2006, 41, 431-434.
43.王為民，夏強(qiáng)，王琳琳，陸源，歷旭云，楊軍*. 大黃素對(duì)大鼠主動(dòng)脈非內(nèi)皮依賴性的舒張作用及其機(jī)制研究. 中國藥學(xué)雜志, 2006, 41, 505-508.
44.王為民，虞燕琴，錢令波，舒強(qiáng)，劉廣義，林茹，楊軍*. 大黃素對(duì)大鼠體外血管內(nèi)皮一氧化氮cGMP信號(hào)途徑的影響. 中國中西醫(yī)結(jié)合雜志, 2006, 26, 636-639.
45.刁匯鈴，朱心強(qiáng)，楊軍*. 復(fù)制蛋白A功能的研究進(jìn)展. 中國藥理學(xué)與毒理學(xué)雜志，2006，印刷中.
46.石為，余艷柯，朱心強(qiáng)，楊軍*. MNNG誘導(dǎo)CHL細(xì)胞中g(shù)ammaH2AX焦點(diǎn)的形成. 癌變，畸變，突變，2006，印刷中.
47.余艷柯，董正偉，石為，劉廣義，楊軍*. MNNG在FL細(xì)胞中誘導(dǎo)一種特殊的gammaH2AX全核染色. 浙江大學(xué)學(xué)報(bào)醫(yī)學(xué)版，2006，印刷中.
* 通訊作者 # 共同第一作者
二、大會(huì)報(bào)告:
1.Yang, J. and Duerksen-Hughes, P. (1996) p53 Induction as an indicator of genotoxic damage. FASEB J. 10(6):AI524, Experimental Biology Annual Meeting 1996, New Orleans, Louisiana
2.Duerksen-Hughes, P., Yang, J., and Schwartz, S. (1999) HPV 16 E6 blocks TNF-mediated apoptosis in mouse fibroblast LM cells. 17th International Papillomavirus Conference, Charleston, South Carolina
3.Duerksen-Hughes, P., Kale, M. D., Ozcan, O., Yang, J., and Zaki, M. (1999) Evaluation of the genotoxicity of chemicals currently undergoing in vivo carcinogenicity testing using the p53-induction assay. Toxicological Sciences, 1742, p369, SOT 1999 Annual Meeting, Seattle, Washington
4.Yang, J., Hooper, W. C., Phillips, D., and Talkington, D. (2001) Regulation of proinflammtory cytokines in human lung epithelial cells by Mycoplasma pneumoniae infection. J. Leukocyte Biol. Suppl.2001:p66, The Cytokine Odyssey 2001, Maui, Hawaii
5.Yang, J., Hooper, W. C., Phillips, D., and Talkington, D. (2002) Regulation of proinflammatory cytokines in human lung epithelial cells during Chlamydia pneumoniae infection. 102nd ASM General Meeting, Salt Lake City, Utah
6.Yang, J., Hooper, W. C., Phillips, D., and Talkington, D. (2002) Cell-type specific interleukin-1beta responses to Mycoplasma pneumoniae infection. 14th International Congress of IOM, Vienna, Austria
7.黃韻, 沈靜, 余應(yīng)年, 楊軍. (2004) MNNG誘導(dǎo)FL細(xì)胞EGF受體聚簇及其對(duì)膜表面脂類代謝影響的研究. 中國病理生理學(xué)會(huì)9th腫瘤病理專業(yè)委員會(huì)及10th免疫病理專業(yè)委員會(huì), 武漢, 湖北
8.楊軍（2005）脂類組學(xué)研究MNNG對(duì)細(xì)胞脂類代謝的影響. 中國21世紀(jì)發(fā)展中心(863環(huán)境資源專題會(huì)議), 上海
9.楊軍(2006) gammaH2AX: Biomarker for DNA double strand breaks. 中國環(huán)境誘變劑學(xué)會(huì)三致專業(yè)委員會(huì)年會(huì), 鄭州, 河南
10.楊軍 （2006）系統(tǒng)生物學(xué)在生命科學(xué)研究中的應(yīng)用. 亞太毒理學(xué)年會(huì)，珠海，廣東
11.曾群力，沈靜，陳帆青，楊軍 （2006）納米碳材料生物安全性的蛋白組學(xué)研究. 78屆東方科技論壇，上海
12.Yang, J. (2006) A genomic, proteomic, and lipidomic response to environmental genotoxin MNNG. 37th Annual Environmental Mutagen Society, Vancouver, Canada
三、參編書籍：
1．生理科學(xué)實(shí)驗(yàn)指導(dǎo)，2004，浙江大學(xué)出版社，夏強(qiáng)主編，路源，魏爾清，楊軍副主編
2．生物醫(yī)學(xué)論著的英文寫作（第二版），2005，浙江大學(xué)出版社，魏爾清主編
3．病理生理學(xué)（八年制），2005，人民衛(wèi)生出版社，陳主初主編
四、研究基金
1．國家重點(diǎn)基礎(chǔ)研究與發(fā)展計(jì)劃（973）No. 2002CB512902 典型環(huán)境化學(xué)污染物致機(jī)體損傷及防御的基礎(chǔ)研究
參加（負(fù)責(zé)人：盧大儒）￥3,000,000 200.12 – 2007.11
2．國家自然科學(xué)基金 No. 30300277 MNNG誘導(dǎo)的細(xì)胞表面受體聚簇的機(jī)理研究
負(fù)責(zé)人 ￥190,000 2004.01 – 2006.12
3．教育部回國人員啟動(dòng)基金
負(fù)責(zé)人 ￥25,000 2004.01 – 2005.12
4．國家高技術(shù)研究計(jì)劃（863）No. 2004AA649120 應(yīng)用H2AX檢測(cè)環(huán)境遺傳毒物的可能性研究
負(fù)責(zé)人 ￥270,000 2004.07 – 2006.6
5．國家自然科學(xué)基金 No. 30471956 MNNG誘導(dǎo)的細(xì)胞脫落蛋白的分離鑒定
負(fù)責(zé)人 ￥210,000 2005.01 – 2007.12
6．霍英東基金會(huì)青年教師基金 No. 101036
負(fù)責(zé)人 USD 20,000 2006.03 – 2009.03
7．教育部新世紀(jì)優(yōu)秀人才支持計(jì)劃 No. NCET-05-0520
負(fù)責(zé)人 ￥500,000 2006.01 – 2008.12
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