業(yè)績一覽：
一、發(fā)表文章:
1.Yang, J. and Duerksen-Hughes, P. (1998) A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage. Carcinogenesis, 19, 1117-1125
2.Duerksen-Hughes, P., Yang, J., and Oczan, O. (1999) p53 induction as a genotoxic test for twenty-five chemicals undergoing in vivo carcinogenicity testing. Env. Health
Persp., 107, 805-812
3.Duerksen-Hughes, P., Yang, J., and Schwartz, S. (1999) HPV 16 E6 blocks TNF-mediated apoptosis in mouse fibroblast LM cells. Virology, 264, 55-65
4.Yang, J. and Duerksen-Hughes, P. (2001) Activation of a p53 independent, sphingolipid-mediated cytolytic pathway in p53-negative mouse fibroblast cells treated with N-methyl-N-nitro-N-nitrosoguanidine. J. Biol. Chem., 276, 27129-27135
5.Yang, J.*, Hooper, W. C., Phillips, D., and Talkington, D. (2002) Regulation of proinflammatory cytokines in human lung epithelial cells during Mycoplasma pneumoniae infection. Infect. Immun., 70, 3649-3655.
6.Yang, J., Hooper, W. C., Phillips, D., Tondella, M., and Talkington, D. (2002) Centrifugation of human lung epithelial carcinoma A549 cells up-regulates interleukin-1beta gene expression. Clin. Diagn. Lab. Immunol. 9, 1142-1143.
7.Yang, J., Hooper, W. C., Phillips, D., Tondella, M., and Talkington, D. (2003) Induction of proinflammatory cytokines in human lung epithelial cells during Chlamydia pneumoniae infection. Infect. Immun. 71, 614-620.
8.Yang, J., Hooper, W. C., Phillips, D., and Talkington, D. (2003) Interleukin-1beta responses to Mycoplasma pneumoniae infection are cell-type specific. Microbial Pathog., 34, 17-25.
9.Yang, J., Yu, Y., and Duerksen-Hughes, P. (2003) Protein kinases and their involvement in the cellular responses to genotoxic stress. Mutat. Res.-Rev. Mutat. Res., 543, 31-58.
10.Zhu, F., Jin, C., Song, T., Yang, J., Guo, L., Yu, Y. (2003) Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N’-nitro-N-nitrosoguanidine and its role in mutagenesis. World J. Gastroentol. 9, 888-893.
11.Jin, J., Gao, Z., Guo, L., Yang, J., and Yu, Y. (2003) Altered expression of zinc finger proteins, ADAMs, and integrin-related proteins following treatment of cultured human cells with a low concentration of N-methyl-N'-nitro-N-nitrosoguanidine. Environ. Mol. Mutagen. 41, 344-352.
12.Wang, Z., Wang, G., Yang, J., Guo, L., and Yu, Y. (2003) Activation of Protein Kinase A and Clustering of Cell Surface Receptors by N-methyl-N'-nitro-N-nitrosoguanidine are Independent of Genomic DNA damage. Mutat. Res. 528, 29-36.
13.Yang, J., Yu, Y., Hamrick, H. E., and Duerksen-Hughes, P. (2003) ATM, ATR, and DNA-PK: Initiators of cellular genotoxic stress response. Carcinogenesis, 24, 1571-1580.
14.Yang, J., Xu, Z., Huang, Y., Hamrick, H., Duerksen-Hughes, P., and Yu, Y. (2004) ATM and ATR: sensing DNA damage. World J. Gastroenterol. 10, 155-160.
15.Jin, J., Yang, J., Gao, Z., and Yu, Y. (2004) Proteomic Analysis of Cellular Responses to Low Concentration N-methyl-N’-nitro-N-nitrosoguanidine in human amnion FL cells. Environ. Mol. Mutagen. 43, 93-99.
16.Gao, Z., Jin, J., Yang, J., and Yu, Y. (2004) Zinc finger proteins and other transcription regulators as response proteins in benzo(a)pyrene exposed cells. Mutat. Res. 550, 11-24.
17.Yu, Y., Yang, J., Zhu, F., and Xu, F. (2004) Response of REV3 promoter to N-methyl-N-nitro-N-nitrosoguanidine. Mutat. Res., 550, 49-58.
18.Yang, J., Yu, Y., Sun, S., Duerksen-Hughes, P. (2004) Ceramide and other sphingolipids in cellular response. Cell Biochem. Biophys., 40, 323-350.
19.Yang, J., Phillips, D., Hooper, W. C., and Talkington, D. F. (2004) Cytokines in Mycoplasma pneumoniae infections. Cytokine Grow. Factor. Rev., 15, 157-168.
20.Shi, B., Cai, Z., Yang, J., and Yu, Y. (2004) N-methyl-N-nitro-N- nitrosoguanidine sensitivity, Mutator phenotype and Sequence specificity of spontaneous mutagenesis in FEN-1 deficient cells. Mutat. Res., 556, 1-9.
21.Gao, Z., Yang, J., Huang, Y., and Yu, Y. (2005) N-methyl-N-nitro-N-nitrosoguanidine interferes with the epidermal growth factor receptor-mediated signaling pathway. Mutat. Res., 570, 175-184.
22.Huang, Y., Yang, J.*, Shen, J., Chen, F., and Yu, Y. (2005) Sphingolipids are involved in N-methyl-N-nitro-N-nitrosoguanidine-induced epidermal growth factor clustering. Biochem. Biophys. Res. Commun., 330, 430-438.
23.Huang, Y., Shen, J., Wang, T., Chen, F., Yu, Y., and Yang, J.* (2005) A lipidomic study of the effects of N-methyl-N’-nitro-N-nitrosoguanidine on sphingomyelin metabolism. Acta Biochim Biophys Sinica, 37, 515-524.
24.Zhou, C., Li, Z., Diao, H., Yu, Y., Zhu, W., Dai, Y., Chen, F.F., and Yang, J.* (2006) DNA damage evaluated by H2AX foci formation by a selective group of chemical/physical stressors. Mutat. Res., 604, 8-18.
25.Yu, Y., Zhu, W., Diao, H., Zhou, C., Chen, F.F., and Yang, J.* (2006) A comparative study of using comet assay and H2AX foci formation in the detection of N-methyl-N’-nitro-N-nitrosoguanidine. Toxicology in Vitro, 20, 959-965.
26.Luo, Q., Yang, J., Zeng, Q., Zhu, X., Qian, Y., and Huang, H. (2006) 50 Hz Electromagnetic Fields Induce gammaH2AX Foci Formation in Mouse Preimplantation Embryos in vitro. Biol. Reproduction, Published on July 19, 2006 as DOI:10.1095/biolreprod.106.052241
27.Li, Z., Yang, J.#, and Huang, H. (2006) Oxidative stress induces H2AX phosphorylation in human spermatozoa. FEBS Lett., In press.
28.Li, Z., Yang, J., and Huang, H. (2006) Adriamycin induces H2AX phosphorylation in human spermatozoa. Biol. Reproduction, In revision.
29.余應年，楊軍. 化學誘變劑誘發(fā)基因非定標性突變的分子機理研究. 浙江大學學報醫(yī)學版, 2003, 32:369-374.
30.金靜華，高志華，楊軍，余應年. 低濃度MNNG誘發(fā)FL細胞應答反應的蛋白組學研究. 浙江大學學報醫(yī)學版, 2003, 32:375-379.
